Cd19 And Cd20 Normal Range

Cd20 is a protein that is expressed on the surface of b cells starting at the pre b cell stage and also on mature b cells in the bone marrow and in the periphery.

Cd19 and cd20 normal range.

Cd19 is expressed on all normal mitogen stimulated and malignant b cells excluding plasma cells. Shearer wt et al. Lymphocyte subsets in healthy children. Cd19 expression is even maintained in b lineage cells that undergo neoplastic transformation.

The percentages of b cells were evaluated with the expression of cd10 cd19 and cd20. The result and loinc information listed below should not be used for electronic interface maintenance with quest diagnostics. Reference ranges for cd10 cd19 and cd20 were found to be 1 3 median 1 6 23 median 14 and 6 23 median 14 respectively table 2. Anti cd20 therapies are used to treat patients with various types of b cell lymphoma leukemia and immune disorders.

The anti cd20 mab ofatumumab was approved by fda in october 2009 for chronic lymphocytic leukemia. Cd20 is the target of the monoclonal antibodies rituximab ocrelizumab obinutuzumab ofatumumab ibritumomab tiuxetan tositumomab and ublituximab which are all active agents in the treatment of all b cell lymphomas leukemias and b cell mediated autoimmune diseases. The distribution of these b cell subsets reference ranges based on gender is shown in table 3. Lymphocyte sub set normal ranges.

Cd20 is not expressed on hematopoietic stem cells pro b cells or normal plasma cells 1 plasmablasts and stimulated plasma cells may express cd20 2 cd20 is generally coexpressed on b cells with cd19 another b cell. The cd19 antigen plays an important role in clinical oncology. 7 18 because of its ubiquity on all b cells it can function as a b cell marker and a target for immunotherapies targeting neoplastic lymphocytes. Lymphocytes absolute cd19 cells cd19 b cells methodology.

Adult normal range chart. Cd19 6 3 20 0 cd16 56 3 2 23 7 ratio 1 0 3 6 absolutes 18 yrs cd3 678 2504 cd3 4 414 1679 cd3 8 162 1038 cd19 96 515 cd16 56 45 523 lymphocyte subset normal range chart. Cd19 and cd20 monitoring. Clotted samples cannot be tested.

It s a protein found on the surface of b cells a type of white blood cell. Pediatric normal range chart. Reference range s see laboratory report.